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This results in excessive synaptic monoamine concentrations, the overstimulation of postsynaptic receptors, and excitatory neurotoxicity

We speculate that the intracellular generation of an uncapped C-terminus and its associated negative charge results in the peptide being better retained in the intracellular space, thus potentially contributing to the enhanced cellular activity

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Key markers include fasting glucose and insulin (to assess insulin sensitivity), HbA1c (long-term glucose regulation), lipid panel (triglycerides, HDL, LDL), resting metabolic rate via indirect calorimetry, and body composition via DEXA scan (to differentiate fat loss from lean mass changes)